TB-500

Thymosin Beta-4 Fragment

TB-500 is the systemic counterpart to BPC-157. Where BPC works best near the injection site, TB-500 travels through your bloodstream and promotes healing wherever inflammation is happening. It upregulates actin, which drives cell migration and wound repair. Most people run it alongside BPC-157 — BPC for the targeted fix, TB-500 for the full-body tune-up. The loading/maintenance structure means you front-load healing then taper down.

Protocol

Dose: 2-2.5mg per injection | Frequency: 2x/week during loading (4-6 weeks), then 1x/week maintenance | Cycle: 6-12 weeks total, then 4 weeks off | Route: SubQ

Reconstitution: 2mL bacteriostatic water per 5mg vial. Use our free reconstitution calculator for exact syringe units.

Effects

• Systemic recovery (72%) — Broad reduction in recovery time from training, injury, or surgery
• Joint mobility (60%) — Improved range of motion and reduced stiffness, especially in chronically inflamed joints
• Reduced inflammation (58%) — Users report less overall soreness and faster resolution of acute inflammation
• Hair growth (25%) — Anecdotal but commonly reported — some users notice thicker or faster-growing hair

Side Effects

• Injection-site irritation (15%) — Little red bump where you pinned. Clears within a day. Rotate your spots.
• Fatigue (12%) — You might feel wiped for a day or two after pinning, especially during loading. Your body's prioritizing repair.
• Lightheadedness (8%) — Brief head rush right after pinning. Sit down for a minute and it passes.
• Headache (6%) — Mild headache sometimes, more likely if you're dosing on the higher end.

Evidence

Emerging evidence — TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring protein your body already makes. Strong preclinical data on wound healing, cardiac repair, and inflammation. No completed human RCTs, but the parent protein (thymosin beta-4) has been in clinical trials for wound healing and dry eye.

Approval status: Not approved

References

1. Malinda KM, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol, 1999. PMID: 10469335
2. Bock-Marquette I, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 2004. PMID: 15565145
3. Guarnera G, et al. Thymosin beta-4 and venous ulcers: clinical remarks on a European prospective, randomized study on safety, tolerability, and enhancement on healing. Ann N Y Acad Sci, 2007. PMID: 17495250
4. Philp D, et al. Thymosin beta 4 induces hair growth via stem cell migration and differentiation. Ann N Y Acad Sci, 2007. PMID: 17947589
5. Goldstein AL, et al. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther, 2012. PMID: 22074294
6. Gao X, et al. Thymosin Beta-4 Induces Mouse Hair Growth. PLoS One, 2015. PMID: 26083021

Storage

• Lyophilized: Refrigerate for long-term storage. Stable at room temperature for short periods during shipping.
• Reconstituted: Refrigerate at 2-8C. Use within 3-4 weeks.
• Water: Bacteriostatic water, 2mL per 5mg vial.
• Needle: 29-30 gauge, 0.5 inch for subcutaneous injection

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These statements have not been evaluated by the FDA. This content is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any protocol.

vialprep research · Sources: PubMed, FDA, peer-reviewed trials · How we verify