3 questions about switching.
Take your last sema dose, start tirz the following week at the lowest dose (2.5 mg). Doesn't matter what sema dose you were on — start low. Titrate up in 2.5 mg steps every 4 weeks. Don't jump to a high tirz dose because you were on high sema. They hit different receptors and there's no validated dose equivalence. Expect some GI adjustment even if sema was smooth for you. They're related but they're not the same drug. Go slow.
Same molecule, different container. You'll need: vials of your peptide (requires prescription from a compounding pharmacy), insulin syringes (29-31 gauge, 0.5 or 1 ml), BAC water, and alcohol swabs. Use the reconstitution calculator to figure out how many units to draw for your current dose. The learning curve is about 2 injections. By your third one it feels routine. The main adjustment is that you're measuring your own dose now, so take your time and double-check the math until it's second nature.
Pens: convenient (dial and click), no reconstitution, harder to mess up dosing, FDA-approved packaging. Downside: expensive ($1,000-1,350/month branded), fixed dose increments (can't microdose), limited flexibility. Vials: much cheaper ($150-400/month compounded), full dose flexibility (microdose, split dose, custom titration), same molecule. Downside: you need to learn syringe technique, there's a reconstitution step, and there's more room for user error. Most people start on pens for simplicity and switch to vials once cost or dosing flexibility becomes a priority.
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