BPC-157

Body Protection Compound 157

BPC-157 is where most people start, and for good reason. It's got the deepest bench of animal research showing accelerated healing of tendons, ligaments, gut lining, and brain tissue. Nobody's run a proper human trial yet, so the doses everyone uses are extrapolated from rats. But the community data is enormous and the side effects are genuinely mild. Your body already makes this compound naturally — it's a stomach peptide. You're just giving it more of what it knows how to use.

Protocol

Dose: 250-500mcg per day | Frequency: Once daily, or split AM/PM for higher doses | Cycle: 4-8 weeks on, 2-4 weeks off | Route: SubQ

Reconstitution: 2mL bacteriostatic water per 5mg vial. Use our free reconstitution calculator for exact syringe units.

Effects

• Tendon & ligament repair (78%) — Most users report noticeable improvement in nagging tendon injuries within 2-4 weeks
• Gut healing (65%) — IBS, leaky gut, and post-antibiotic recovery are the most commonly cited gut benefits
• Reduced inflammation (55%) — General reduction in chronic low-grade inflammation reported across joints and soft tissue
• Faster wound healing (45%) — Cuts, surgical sites, and skin injuries seem to close faster during active cycles

Side Effects

• Injection-site redness (18%) — You might get a little red bump where you pinned. Goes away in about an hour. Not cute but not serious.
• Fatigue (9%) — First few days you might feel wiped. Your body's adjusting. Start low and it's usually fine.
• Nausea (5%) — Mild nausea sometimes, especially if you pin on an empty stomach. Eating something first helps.
• Dizziness (3%) — Quick head rush right after pinning. Gone in a minute. Sit down if it hits you.

Evidence

Emerging evidence — Hundreds of rodent studies showing jaw-dropping healing across tendons, gut, and brain. First human safety data dropped in 2025 (n=2, IV infusion, no adverse events), but there are still zero published human RCTs. The community is way ahead of the science here.

Approval status: Not approved

References

1. Seiwerth S, Brcic L, Vuletic LB, et al. BPC 157 and blood vessels. Curr Pharm Des, 2014. PMID: 25312743
2. Chang CH, Tsai WC, Lin MS, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol, 2011. PMID: 21030672
3. Sikiric P, Rucman R, Turkovic B, et al. Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157. Vascular recruitment and gastrointestinal tract healing. Curr Pharm Des, 2018. PMID: 29782919
4. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res, 2019. PMID: 31203428
5. Vukojevic J, Siroglavic M, Kasnik K, et al. Rat inferior caval vein (ICV) ligature and BPC 157. Therapy potential. J Pharmacol Sci, 2018. PMID: 30266468

Storage

• Lyophilized: Room temperature is fine for shipping, but refrigerate (2-8C) for long-term storage. Stable for 12+ months sealed.
• Reconstituted: Refrigerate immediately. Use within 4-6 weeks. Never freeze after reconstitution.
• Water: Bacteriostatic water (not sterile water). 2mL per 5mg vial is standard.
• Needle: 29-31 gauge, 0.5 inch for subcutaneous injection

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These statements have not been evaluated by the FDA. This content is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any protocol.

vialprep research · Sources: PubMed, FDA, peer-reviewed trials · How we verify